Izvorni kôd stranice Tirozin-tRNK ligaza

{{Infokutija enzim
| ime             = Tirozin-tRNK ligaza
| EC_number       = 6.1.1.1
| CAS_number      = 9023-45-4
| IUBMB_EC_number = 6/1/1/1
| GO_code         = 0004831
| image           =
| width           =
| caption         =
}}
'''Tirozin-tRNK ligaza''' (EC broj|EC 6.1.1.1) – u [[enzimologija|enzimologiji]] – je [[enzim]] koji [[kataliza|katalizira]] [[hemijska reakcija|hemijsku reakciju]]:

:[[ATP]] + L-[[tirozin]] + [[RNK]] <math>\rightleftharpoons</math> [[AMP]] + difosfat + L-tirozil-tRNK T

Tri [[supstrat (biohemija)|supstrata]] ovog enzima su:
[[ATP|adenozin trifosfat]] (ATP), [[L-tirozin]] i [[RNK]], dok su mu tri [[proizvod (hemija)|proizvoda]]: [[adenozin monofosfat|AMP]], [[difosfat]] i [[L-tirozil-tRNK(Tyr)]].

Ovaj [[enzim]] pripada porodici [[ligaza]], za specifično formiranke [[ugljik]]-[[kisik]]veza u aminoacil-tRNK i srodnim spojevima. [[Spisak enzima|Sistemsko ime]] njegove klase je '''L-tirozin:tRNATyr ligaza (AMP-formirajuća)'''. Ovaj enzim učestvuje u biosintezi aminokiselina [[fenilalanin]]a, [[tirozin]]a i [[triptofan]]a, kao i [[aminoacil-tRNK]].

== Strukturne studije ==
Krajem [[2007]]. riješene su 34 strukture ove klase enzima sa pristupnim kodovima u [[Proteinska banka podataka|Proteinskoj bazi podataka]]: {{PDB link|1H3E}}, {{PDB link|1J1U}}, {{PDB link|1JH3}}, {{PDB link|1JII}}, {{PDB link|1JIJ}}, {{PDB link|1JIK}}, {{PDB link|1JIL}}, {{PDB link|1N3L}}, {{PDB link|1NTG}}, {{PDB link|1Q11}}, {{PDB link|1TYA}}, {{PDB link|1TYB}}, {{PDB link|1TYC}}, {{PDB link|1TYD}}, {{PDB link|1U7D}}, {{PDB link|1U7X}}, {{PDB link|1VBM}}, {{PDB link|1VBN}}, {{PDB link|1WQ3}}, {{PDB link|1WQ4}}, {{PDB link|1X8X}}, {{PDB link|1Y42}}, {{PDB link|1ZH0}}, {{PDB link|1ZH6}}, {{PDB link|2AG6}}, {{PDB link|2CYA}}, {{PDB link|2CYB}}, {{PDB link|2CYC}}, {{PDB link|2DLC}}, {{PDB link|2HGZ}}, {{PDB link|2J5B}}, {{PDB link|2TS1}}, {{PDB link|3TS1}}, and {{PDB link|4TS1}}.

== Reference ==
{{Refbegin}}
* {{cite journal |authors = ALLEN EH, GLASSMAN E, SCHWEET RS | year = 1960 | title = Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes |url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-04_235_4/page/1061 | journal = J. Biol. Chem. | volume = 235 | pages = 1061–7 | pmid = 13792726 }}
* {{cite journal | authors = Cowles JR, Key JL | year = 1972 | title = Demonstration of two tyrosyl-tRNA synthetases of pea roots | journal = Biochim. Biophys. Acta | volume = 281 | pages = 33–44 | pmid = 4563531 | issue = 1 | doi=10.1016/0005-2787(72)90185-2}}
* {{cite journal | authors = HOLLEY RW, BRUNNGRABER EF, SAAD F, WILLIAMS HH | year = 1961 | title = Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of patassium ions on the activity of the tyrosine enzyme | url = https://archive.org/details/sim_journal-of-biological-chemistry_1961-01_236_1/page/197 | journal = J. Biol. Chem. | volume = 236 | pages = 197–9 | pmid = 13715350 }}
* {{cite journal |author1 = Schweet RS |author2 =Allen EH | year = 1958 | title = Purification and properties of tyrosine-activating enzyme of hog pancreas |url = https://archive.org/details/sim_journal-of-biological-chemistry_1958-11_233_5/page/1104 | journal = J. Biol. Chem. | volume = 233 | pages = 1104–1108 | pmid=13598741}}
* {{cite journal | authors = Brick P, Bhat TN, Blow DM | year = 1989 | title = Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution Interaction of the enzyme with the tyrosyl adenylate intermediate | journal = J. Mol. Biol. | volume = 208 | pages = 83–98 | pmid = 2504923 | doi = 10.1016/0022-2836(89)90090-9 | issue = 1 }}
{{Refend}}

{{Enzimi}}

[[Kategorija:EC 6.1.1]]
[[Kategorija:Enzimi poznate strukture]]